报告题目：Non-linear waves and Cardiac arrhythmias
报 告 人：Prof. Alexander V. Panfilov (Ghent University, Belgium)
Sudden cardiac death as a result of cardiac arrhythmias is the leading cause of death in the world. Although cardiac arrhythmias have been studied well over a century, their underlying mechanisms remain largely unknown. One of the main problems is that cardiac arrhythmias occur at the level of the whole organ only. But in most cases, only single cell experiments can be performed. Due to these limitations, alternative approaches, such as multiscale computer modelling of the heart, are currently of great interest. From mathematical point of view, excitation of the heart is described by a system of non-linear parabolic partial differential equations of the reaction diffusion type with anisotropic diffusion operator. Cardiac arrhythmias correspond to the solutions of these equations in form of 2- or 3-dimentional vortices characterized by their filaments.
In my talk, I will explain the mechanisms of cardiac arrhythmias from basics and present the main ideas behind the multiscale computer modelling of the heart. Then, I will report on the research directions of my group, specifically on development of virtual human heart model and its application to study the mechanisms of sudden cardiac death. I will also report on how modelling can be used in combination with new experimental technologies in the field, such as cardiac cell cultures and optogenetics and discuss their possible application for treatment of cardiac arrhythmias.
Prof. Alexander V. Panfilov got his Ph.D. of Biophysics in Institute of Biological Physics, USSR Academy of Sciences in 1983. He worked at the Institute of Biological Physics, USSR Academy of Sciences until 1990. Then, he got a tenured position in Utrecht University, The Netherlands, in 1992-2011. And he is a professor in Gent University, Belgium, since 2011. He is also an honorary professor in University of Dundee, Scotland since 2005, and a guest professor in the Heart Lung Centre at Leiden University Medical Centre, Netherlands since 2017. He is an editor of PLOS Computational Biology, PLOS One, and Frontiers in Computational Physiology, and a reviewer for Nature, Science, PNAS etc. His current Web of Science h-index is 43.